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Professor Augustine Arukwe is a molecular toxicologist at the Department of Biology, Norwegian University of Science and Technology (NTNU) Trondheim and European registered toxicologist. In this presentation, Dr. Arukwe will use two animal models (fish and rodents) as proxies for different taxa and humans in explaining the role(s) played by environmental contaminants in the prevalence of metabolic disorders. The application of one health and systems toxicology in understanding toxicological mode-of-action and associated adverse outcomes, requires a multidisciplinary approach, where omics technologies is in harmony with molecular and cell biology, physiology, pathology, marine science, environmental chemistry, ecology, as well as computational biology.